Name | Pemetrexed disodium hydrate |
Synonyms | LY-231514 Disodium Hydrate Pemetrexed disodium 2.5H2O Pemetrexed disodium hydrate Pemetrexed disodium 2.5 hydrate Pemetrexed Disodium hemipenta hydrate PeMetrexed DisodiuM heMipenta hydrate N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid disodium salt hydrate 2-[4-[2-(4-Amino-2-oxo-3,5,7-triazabicyclo[4.3.0]nona-3,8,10-trien-9-yl)ethyl]benzoyl]aminopentanedioic acid disodium salt hydrate |
CAS | 357166-30-4 |
EINECS | 814-356-7 |
InChI | InChI=1/C20H21N5O6.2Na.H2O/c21-20-24-16-15(18(29)25-20)12(9-22-16)6-3-10-1-4-11(5-2-10)17(28)23-13(19(30)31)7-8-14(26)27;;;/h1-2,4-5,9,13H,3,6-8H2,(H,23,28)(H,26,27)(H,30,31)(H4,21,22,24,25,29);;;1H2/q;2*+1;/p-2/t13-;;;/m0.../s1 |
Molecular Formula | 2(C20H19N5Na2O6).5(H2O) |
Molar Mass | 1032.84 |
Melting Point | 274-276°C (dec.) |
Solubility | <1 mg/ml means slightly soluble or insoluble., , , <1 mg/ml means slightly soluble or |
Appearance | Solid |
Color | Off-White |
Storage Condition | Room Temperature |
In vitro study | Pemetrexed disodium showed antitumor activity in CCRF-CEM leukemia, GC3/C1 colon cancer, and HCT-8 ileocecal colon cancer cells with IC50 of 25 nM,34 nM, and 220 nM, respectively. A recent study showed that cisplatin and Pemetrexed combined to SOCS-1 gene transfer, by inhibiting cell proliferation and invasion, as well as inducing apoptosis in MPM cells infected with adenovirus-expressing SOCS-1 vectors, exhibiting antitumor effects. |
In vivo study | Pemetrexed disodium produces a persistence-dependent tumor growth delay (TGD) in human H460 non-small cell lung cancer xenografts. |
biological activity | Pemetrexed Disodium Hydrate (LY-231514) pemetrexed is a new type of anti-folate and anti-metabolic substance, acting on TS,DHFR and GARFT,Ki is 1.3 nM,7.2 nM and 65 nM respectively. Pemetrexed Disodium Hydrate can stimulate autophagy and apoptosis. |
Target | Value |
TS | 1.3 nM(Ki) |
DHFR | 7.2 nM(Ki) |
GARFT () | 65 nM(Ki) |